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產(chǎn)品名稱：Smartox-Biotech
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Smartox-Biotech于2009年由來(lái)自Grenoble神經(jīng)科學(xué)研究所(Grenoble Institute of Neuroscience)的Michel de waard博士創(chuàng)立,Smartox-Biotech專門研究動(dòng)物毒液，制作合成多種毒液中的多肽成分（常稱為**）。De Waard博士研究離子通道與**多肽的關(guān)系，尤其是鑒定、開(kāi)發(fā)**多肽作為**性分子或細(xì)胞穿透肽(cell penetrating peptides, CPP)。

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Smartox-Biotech

Smartox Biotechnology

離子通道研究用多肽**的專業(yè)化生產(chǎn)商

Smartox Biotechnology是全球唯壹一家專門生產(chǎn)動(dòng)物毒液多肽**，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽**在生物制藥領(lǐng)域具有重要的使用價(jià)值。

Smartox Biotechnology于2009年由來(lái)自Grenoble神經(jīng)科學(xué)研究所(Grenoble Institute of Neuroscience)的Michel de waard博士創(chuàng)立,Smartox Biotechnology專門研究動(dòng)物毒液，制作合成多種毒液中的多肽成分（常稱為**）。De Waard博士研究離子通道與**多肽的關(guān)系，尤其是鑒定、開(kāi)發(fā)**多肽作為**性分子或細(xì)胞穿透肽(cell penetrating peptides, CPP)。其研究團(tuán)隊(duì)在毒液分離，藥理性活性肽鑒定、富半胱氨酸肽定性、制作和優(yōu)化等方面具有獨(dú)特、豐富的經(jīng)驗(yàn)。2010年，Smartox Biotechnolgy被法國(guó)研究部(Ministry of Research)授予“新興企業(yè)OSEO獎(jiǎng)(OSEO prize for emerging businesses)”。

總之，Smartox Biotechnology提供一系列高質(zhì)量、具開(kāi)創(chuàng)價(jià)值的多肽**。這些化合物在離子通道研究中具有高的親和性和選擇性，是相應(yīng)領(lǐng)域科學(xué)研究理想的生物**提供商和貼心的合作伙伴。

Smartox Biotechnology的**產(chǎn)品包括：

鈉離子通道(Sodium channel)

Toxin name	Catalog #	Target
Phrixotoxin-3	13PHX003	Selective blocker of Na_v1.2
μ-conotoxin GIIIB	CON020	Selective blocker of Na_v1.4
μ-conotoxin CnIIIC	CON021	Selective blocker of Na_v1.4
μ-conotoxin PIIIA	08CON006	Selective blocker of Na_v1.4
Jingzhaotoxin-III	12JZH003	Selective blocker of Na_v1.5
ProTx-II	07PTX002	Selective blocker of Na_v1.7
ProTx-II Biotin	12PTB002	Selective blocker of Na_v1.7
ProTx-I	12PTX001	Blocker of Na_v1.8, Na_v1.2, Na_v1.5, Na_v1.7
Huwentoxin-I	07HWT001	Blocker of TTX-S
Huwentoxin-IV	08HWT002	Blocker of TTX-S
Hainantoxin-III	13HTX003	Blocker of TTX-S
Hainantoxin-IV	12HTX001	Blocker of TTX-S
GsAF-I	12GSF001	Blocker of TTX-S
GsAF-II	12GSF002	Blocker of TTX-S

鉀離子通道(Potassium channel)

K_Ca channels
Toxin name	Catalog #	Target	Description
Apamin	08APA001	SK1, SK2, SK3
Charybdotoxin	11CHA001	K_Ca1.1, K_Ca3.1 - K_v1.2, K_v1.3, K_v1.6
Iberiotoxin	12IBX001	K_Ca1.1
Leiurotoxin 1 (Scyllatoxin)	10LEI001	SK1, SK2, SK3
Tamapin	10TAM001	SK1, SK2, SK3
Kaliotoxin-1	08KTX002	BK, K_v1.1, K_v1.2, K_v1.3

K_v channels
ShK	08SHK001	K_v1.3, K_v1.1, K_v1.4, K_v1.6
TMR-ShK	SAT001	K_v1.3, K_v1.1
Margatoxin	08MAG001	K_v1.3
(Dap22)-ShK	13SHD001	K_v1.3
ADWX-1	13ADW001	K_v1.3
HsTx1	08NEU001	K_v1.3, K_v1.2
Agitoxin-2	13AGI002	K_v1.3, K_v1.1
Maurotoxin	08MAR001	K_v1.2, K_Ca3.1
Guangxitoxin 1E	11GUA002	K_v2.1, K_v2.2
Stromatoxin 1 ^NEW	SCT01	Kv2.1, Kv2.2
Kaliotoxin-1	08KTX002	BK, K_v1.1, K_v1.2, K_v1.3
Charybdotoxin	11CHA001	K_Ca1.1, K_Ca3.1 - K_v1.2, K_v1.3, K_v1.6
Phrixotoxin-2	PHX002	Kv4.2, Kv4.3
AmmTx3 ^NEW	AMX001	A-type potassium channels

Inwardly rectifying potassium channels
TertiapinQ	08TER001	K_ir1.1, K_ir3.1/3.4, K_ir3.1/3.2-K_Ca1.1

hERG/K_v11.1
BeKm-1	13BEK001	ERG1

鈣離子通道(Calcium channel)

High voltage-gated Ca²⁺ channels
Toxin name	Catalog#	Target	Description
ω-agatoxin IVA	11AGA001	P/Qtype
ω-Conotoxin MVIIC	08CON002	P/Qtype, N-type
ω-Conotoxin MVIIA	08CON001	N-type
ω-Conotoxin GVIA	08CON003	N-type
ω-Conotoxin SO3	08CON013	N-type
Huwentoxin I	07HWT001	N-type
ProTx-II	07PTX002	T-type, L-type

Intermediate voltage-gated Ca²⁺ channels
SNX482	08SNX002	R-type

Low voltage-gated Ca²⁺ channels
ProTx-I	12PTX001	T-type
ProTx-II	07PTX002	T-type, L-type

Ryanodine receptors
Maurocalcine	07PAU001	Ryr1

氯離子通道(Chloride channel)

Toxin name	Catalog #	Target	Description
Chlorotoxin	08CHL001	Blocker of small conductance Cl^- channels
GaTx1	13GTX001	Selective blocker of CFTR channel
GaTx2	10GTX002	Selective blocker of ClC-2 channel

乙酰膽堿受體(Acetylcholine receptor)

Toxin name	Catalog #	Target	Description
α-conotoxin PeIA	13CON017	α9α10, α3β2 subunits
αC-Conotoxin PrXA	13CON016	α1/β1/ε/δ, α1/β1/γ/δ subunits
Waglerin-1	12WAG001	MusclenAChR
α-conotoxin MI	08CON012	α1/δsubunits
α-conotoxin GI	08CON005	α/δsite
α-conotoxin IMI	08CON011	α7 homomeric nAChR
α-conotoxin GID	CON019	Blocker of α3β2, α7 and α4β2 nAChRs

含N-甲基-D-天冬氨酸NR2B (NMDA, NR2B containing N-methyl-D-aspartate)

Conantokin-G選擇性、特異性抑制含NR2B的NMDAR。Conantokin-G能劑量依賴性抑制Ca²⁺內(nèi)流，抑制NMDA誘導(dǎo)的興奮性中毒效應(yīng)。研究表明，在小鼠皮層神經(jīng)元，Conantokin-G阻滯NMDA引發(fā)的電流信號(hào)的IC50值為480 nM。

酸敏感離子通道(ASIC channel, Acid-Sensing Ion Channel)

Toxin name	Catalog #	Target	Description
APETx2	07APE002	Selective blocker of ASIC3
Psalmotoxin1/PcTx1	13PCT001	Selective blocker of ASIC1a
Ugr9-1	13UGR001	Blocker of ASIC3

瞬時(shí)受體電位(TRP channel, transient receptor potential)

Toxin name	Catalog #	Target	Description
GsMTx4	08GSM001	TRPC, TRPA
Vanillotoxin3	10VAN003	Activator of TRPV1
ProTx-I	12PTX001	Antagonist of TRPA1

嘌呤能通道(Purinergic channel)

Purotoxin-1

選擇性抑制P2X3受體。100 nM Purotoxin-1 (PT-1)選擇性抑制P2X3受體通道，在大鼠DRG神經(jīng)元上，使用膜片鉗實(shí)驗(yàn)表明：PT-1對(duì)電壓門控通道和TRPV1均無(wú)抑制效應(yīng)。10 μM ATP和100 μM α,β Methylene-ATP濃度下Purotoxin-1對(duì)P2X3受體有選擇性作用，在該ATP濃度下Purotoxin-1對(duì)P2X2和雜化二聚體P2X2/3并無(wú)激動(dòng)作用。

Purotoxin-1對(duì)疼痛的潛在**作用。

其它膜受體通道(Others)

Smartox Biotechnology還提供其他類型的膜受體抑制劑：

Toxin name	Catalog#	Target
Morphiceptin	011CAS001	Agonist of μ-opoid receptors
Lys-conopressin G	11CON14	Vasopressin-like peptide
GsMTx4	08GSM001	Mechano sensitive ion channels
Obtustatin	10OBT001	Blocks the binding of α₁β₁ integrin to collagen IV
Rho-Conotoxin TIA	CON022	Blocks α₁-adrenergic receptor

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產(chǎn)品名稱：Smartox-Biotech

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